Dutch Data Prize – Cell Subset Explorer

Most datasets in this catalog are FAIR and machine-accessible through our FAIR Data Point ( fdp.lucid.lumc.nl ). For the Dutch Data Prize and effortless reusability, we've created an open dataset to showcase the results of our FAIRification tool ( github.com/koenAStam/beFAIR ). We have brought together summary analyses from several of our mass cytometry datasets, offering researchers a direct window into cellular immunology across rare and unique controlled human infection studies. These include, for example, PfGA2, the first malaria challenge trial using genetically attenuated sporozoites, and CoHSI1, the first Schistosoma mansoni challenge trial in Europe. Furthermore, trials from endemic areas are also included, showcasing the differences between the immune profiles of participants from non-endemic and endemic regions, a key missing link in developing effective vaccines against parasitic infections. This is highlighted by the prinicpal component analysis that splits the first component on immune profiles based on the ancestry of the participants.